USCIS Application Support Center St Louis, MO: address, hours, ZIP codes

USCIS Application Support Center — St Louis, MO

The Application Support Center - St Louis, MO is a USCIS Application Support Center (ASC) at USCIS Application Support Center, 1222 Spruce Street, Room 1.208, St. Louis, MO 63103-2815. ASCs are the offices where USCIS takes biometrics (fingerprints, photographs and signatures) for applications that require them. In USCIS’s field-office-by-ZIP file dated August 28, 2026, 1203 ZIP codes in 117 counties (IL, MO) are assigned to this ASC.

General information, not legal advice. For your specific case, talk to an immigration attorney or an accredited representative.

Quick reference

Getting there: USCIS driving directions

The ASC’s USCIS page gives these driving directions (quoted as published):

Driving directions are as follows: From the North, take Interstate 70 East. Exit at Memorial Drive. Take a right on Market. Take a left on South Tucker Boulevard. Turn right on Spruce Street. From the South, take Interstate 55 North. Exit at Lafayette Avenue, stay straight to go to Truman Parkway. Turn right onto Chouteau Avenue. Turn left onto 14th Street. Turn right onto Spruce Street. From Illinois, take Interstate 55 and 70 West. Cross the Poplar Street Bridge and take the 9th Street exit. Turn left onto Clark Avenue. Turn left onto South Tucker Boulevard. Turn right onto Spruce Street. From the West, take Interstate 40 East. Exit at 14th Street. Turn left onto 14th Street. Turn right onto Spruce Street.

ZIP codes and counties USCIS assigns to this ASC

USCIS’s field-office-by-ZIP file (dated August 28, 2026) names an ASC for every ZIP code. These are the counties with ZIP codes assigned to the St Louis ASC, with up to four of their cities (most ZIP codes first, then alphabetical). USCIS assigns ZIP codes, not whole counties, so a county can be split between ASCs.

Field offices whose ZIP codes route here (from the same file):

• USCIS Saint Louis Field Office: 937 ZIP codes
• USCIS Kansas City Field Office: 239 ZIP codes
• USCIS Des Moines Field Office: 22 ZIP codes
• USCIS Chicago Field Office: 5 ZIP codes

Before your appointment: what USCIS says

• Go only with a notice. The ASC’s USCIS page says applicants need to appear at the assigned ASC on the appointment notice.
• What to bring. USCIS’s biometrics page lists your ASC appointment notice (Form I-797C), every notice if you received several, and valid photo identification (such as a Green Card, passport or driver’s license).
• Rescheduling. USCIS’s biometrics page says the request must be made through your USCIS online account (not by mail), before the original appointment, with good cause, and at least 12 hours before the appointment time; to use a different ASC you must reschedule in advance and select it. If the request is less than 12 hours from the appointment or you missed it, the page says to call the USCIS Contact Center at 800-375-5283 (TTY 800-767-1833).
• Closures. If the ASC closes for weather or a facility issue, USCIS says it reschedules the appointment automatically; it asks you to check its Office Closings page before traveling.
• No weapons. USCIS says federal law prohibits weapons such as firearms, knives, pepper spray and ammunition at any USCIS facility.

Related information

• USCIS Saint Louis Field Office
• USCIS Kansas City Field Office
• USCIS Des Moines Field Office
• All USCIS offices serving Missouri
• Change of address with USCIS

Last verified: 2026-10-15. General procedural information for educational purposes, not legal advice; for your specific case, consult an immigration attorney or accredited representative. Office data comes from official USCIS pages and files and can change. Your appointment notice is what counts.